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Department of Medicine
Ghosh Laboratory
Signal Transduction Slide
Discovering Novel Interfaces in Signal Transduction
Dr. Pradipta Ghosh 
About the Lab 
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Pradipta Ghosh

Dr. Ghosh obtained her medical degree from Christian Medical College, Vellore, in India.  She started her career in science under the mentorship of Stuart Kornfeld at Washington University in St. Louis, Missouri, before beginning her internship and residency in internal medicine and a postdoctoral training in the laboratory of Marilyn G. Farquhar here at UC San Diego. Her postdoctoral work has directly led to the characterization of a novel stratum in signal transduction by a unique class of molecules, which she christened “molecular rheostats”.

      Since being appointed at UCSD, the Ghosh lab continues to investigate how G proteins and their modulators are regulated by receptor and non-receptor tyrosine kinases /phosphatases that are triggered by growth factors. Her lab strives to discover novel interfaces assembled at the crossroads of G protein and growth factor signaling pathways, and broadly translate their significance  in a multitude of organ systems to study a variety of chronic diseases, e.g., diabetes, cancer metastasis, organ fibrosis; all of which are multi-receptor in origin and frustratingly incurable.

Read Pradipta Ghosh's full bio >

The Ghosh Lab is busy identifying and characterizing novel interfaces within key signaling cascades which serve as “Signal-Amplification-Switches”. The primary function of these switches is “UNRESTRICTED AMPLIFICATION” of signaling cascades, rendering them capable of driving the efficiency of diverse cellular processes beyond physiologic needs (secretion, renewal & healing) and thereby, initiate and promote pathologic processes such as tumor growth, metastasis and fibrogenesis.

Learn More About the Lab:

Lab Location
University of California, San Diego
George Palade Laboratories for Cellular and Molecular Medicine (GPL Building)
Rooms 333, 332 (offices) and 321b (laboratory).

Mailing Address
University of California, San Diego
9500 Gilman Drive #0651
La Jolla, CA 92093-0651

858-822-7633 (office)
858-822-7635 (lab)

Fax: 858-822-7636